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History of Alzheimer's Disease

This summer, I got the opportunity of a lifetime with my internship at a renowned neurology lab at MGH. I am learning so much, not just about scientific processes and research procedures, but also about Alzheimer's disease, a terrible disease afflicting over 35 million people worldwide. Alzheimer’s disease is a progressive (and currently incurable) brain disorder that slowly destroys memory and thinking skills, eventually leading to the inability to carry out even the most basic tasks such as walking and dressing. The lab focuses on the pathological pathway to Alzheimer’s disease, which is still not fully understood. More about my lab research can be found at https://www.massgeneral.org/neurology/research/tanzi-lab-genetics-and-aging.  Alzheimer's disease was first studied by (and is named after) Dr. Alois Alzheimer who was treating a patient with mental illness with severe memory loss, language problems, and unpredictable behavior.  After her death in 1906, Dr. Alzheimer exami

Origin of Neurology

As I consider majoring in neurobiology (the study of the biological mechanisms that control the nervous system) in college, I thought it would be interesting to delve into the origins of neuroscience. For hundreds of years from the ancient Egyptians to the Greeks, humans believed that the seat of intellect was the heart (which is why the ancient Egyptians went to great lengths to preserve the heart after death but discarded the brain!)    The birth of neurology began 2500 years ago with Hippocrates who pondered over the purpose and functioning of the brain, reasoning that the brain must be the organ controlling sensation simply because most sensory organs - eyes, ears, and tongue -- are located close to the brain. This was starkly different from other opinions of the time which held that the heart was the main organ that controlled everything in humans. The brain was simply thought to be a "radiator" for pumping the heart and keeping it cool.  Later, Hippocrates expanded the

Medical Terminology: A Lasting Classical Gift

As we come to accept that the great covid-19 pandemic which started off as an epidemic is slowly becoming  endemic , it's worth noting the new additions to our vocabulary. These words that were likely "all Greek to you" before 2020, are indeed just that -- they are all in fact derived from ancient Greek! The word  epidemic was in use since at least the time of Homer which is around 600 BCE, and is mentioned in the Odyssey to mean "who is back home" or "who is in his country." However, it was first introduced to medical jargon, along with its closely associated words pandemic and endemic , by the ancient Greek doctor, Hippocrates.    Hippocrates' treatise on Epidemics  Evolution of the term Epidemics. Credit: Paul Martin And not just these but several other words that we have come to associate with the current pandemic (as well as other diseases) were also coined by Hippocrates and his medical school such as: Cytokine Chronic Resolution Peak Acute

Left-Handedness

As the only lefty in my immediate family, I have always been intrigued by handedness, which is defined as an individual's preferential use of one hand, also known as the dominant hand. This post is dedicated to all the world's lefties trying to function in a right-handed world (you know what I'm talking about!) For my clueless right-handed friends, think of me when you see a classroom desk, scissors, or a microscope!)  Left-handedness is apparently genetic, so it's all the more surprising that I'm the only one in my family. However, my extended family on my dad's side certainly has some more lefties, so it's not all that strange. Another interesting tidbit that I found was that India has about half as many left-handers as the United States (despite its much larger population), and this is attributed mainly to the cultural aspect of the society. India is known to be a "collectivistic culture", which discourages left-handedness in children, whereas i

May the Fourth Be With You

Happy Star Wars Day on this May the 4th! On this momentous day for Star Wars fans, I wanted to revisit the concept of the "force" that Star Wars borrowed from ancient medicine.   As Obi-Wan Kenobi explains, “The Force is what gives a Jedi his power. It’s an energy field created by all living things. It surrounds us and penetrates us; it binds the galaxy together.”  Pretty heavy stuff!  In an old post, I explored the similarity between this force field and the life force that is an essential component of many ancient civilizations: prana in India, qi in Chinese culture, Japanese  ki, Egyptian ka,  Greek pneuma ,   and the Latin spiritus . All of these are essentially the same "life force energy" that keeps us alive and binds us. Just as Luke Skywalker trains to harness the power of the force, yoga, reiki, taichi and other ancient practices teach how to control and balance the life force present inside of us. So here's wishing everyone boatloads of the force worki

Our Planet, Our Health

For World Health Day 2022, the WHO has selected the theme, "Our Planet, Our Health", with the aim of creating a healthier world. WHO's statement reads,  "In the midst of a pandemic, a polluted planet, increasing diseases like cancer, asthma, heart disease, on World Health Day 2022, WHO will focus global attention on urgent actions needed to keep humans and the planet healthy and foster a movement to create societies focused on well-being."  In the spirit of World Health Day, I wanted to explore the idea of health in ancient medicine. This is a topic that I have written on before but I thought it would be interesting to compare the ideology of good health in different societies of the ancient world. Ancient Medicine Across all ancient civilizations, before scientific thought became common, the prevailing idea was that  good health was a divine gift, while poor health was attributed to divine punishment. Theory of Spirits Even though the ancient Egyptians were one

Gift of the Irish

St. Patrick's Day celebrates the patron saint of the Irish who brought Christianity to Ireland and taught about the Holy Trinity using a three-leafed clover (hence the significance of the clover). Over time, he also came to be associated with healing of several diseases like epilepsy. He is associated with some 50 holy wells in Ireland, whose waters are supposed to help with a variety of ailments from toothache to eye and skin ailments. While these superstitions have long passed, I think it's important to celebrate the contributions of the Irish to modern medicine on a day that celebrates Irish culture and traditions. St. Patrick's Well in Belcoo, Ireland Of all Irish doctors, the story I found most captivating is that of Dr. James Barry, nee Margaret Bulkley, who disguised herself as a man in order to practice medicine in 1790 in Cork, Ireland. She became the first female doctor in all of the U.K. and also the first one to perform a successful caesarian operation. Margaret